Search results for "Reproductive health and childbirth"

showing 6 items of 6 documents

Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease

2018

SUMMARY Maternally skewed transmission of traits has been associated with genomic imprinting and oocyte-derived mRNA. We report canine congenital eye malformations, caused by an amino acid deletion (K12del) near the N terminus of retinol-binding protein (RBP4). The disease is only expressed when both dam and offspring are deletion homozygotes. RBP carries vitamin A (retinol) from hepatic stores to peripheral tissues, including the placenta and developing eye, where it is required to synthesize retinoic acid. Gestational vitamin A deficiency is a known risk factor for ocular birth defects. The K12del mutation disrupts RBP folding in vivo, decreasing its secretion from hepatocytes to serum. T…

0301 basic medicineMaleNon-Mendelian inheritanceProtein Foldingcongenital eye defectEye Diseasesgenetic structuresNATIVE DISULFIDE BONDSMedical PhysiologyRetinoic acidReproductive health and childbirth413 Veterinary scienceMicrophthalmiavitamin Achemistry.chemical_compoundPlasmaA-vitamiini2.1 Biological and endogenous factorsMicrophthalmosPrealbuminCRYSTAL-STRUCTUREAetiologyBase Pairinglcsh:QH301-705.5Sequence DeletionPediatricwhole genome sequencingVITAMIN-A-DEFICIENCYANOPHTHALMIAPenetrancePedigreemedicine.anatomical_structurePhenotypeFemalemedicine.medical_specialtyGenotypeENDOPLASMIC-RETICULUMGenes RecessiveMETABOLISMBiologyGeneral Biochemistry Genetics and Molecular BiologyArticle03 medical and health sciencesDogscanine geneticsInternal medicinePlacentaRETINOL-BINDING-PROTEINGeneticsmedicineAnimalsHumansRecessiveMALFORMATIONSBIOCHEMICAL BASISAmino Acid SequenceAlleleEye Disease and Disorders of VisionNutritiongenome-wide association study030102 biochemistry & molecular biologywestern blottingMUTATIONSta1184RBP4maternal inheritancemedicine.diseaseRetinol-Binding ProteinsRetinol binding proteinnuclear magnetic resonance030104 developmental biologyEndocrinologychemistryGeneslcsh:Biology (General)microphthalmiaGenetic LociHela Cells1182 Biochemistry cell and molecular biologyCongenital Structural Anomalies3111 BiomedicineBiochemistry and Cell BiologyDigestive DiseasesGenomic imprintingRetinol-Binding Proteins PlasmaHeLa Cells
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Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analy…

2019

Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, No…

Data AnalysisembarazoMaternal HealthBlood PressureCHILDRENWeight GainCardiovascularVascular MedicineBody Mass Index0302 clinical medicineEndocrinologyPregnancyMedicineMass indexestudios de cohortesCancer030219 obstetrics & reproductive medicineStatisticsWOMENta3141General Medicine030220 oncology & carcinogenesisMeta-analysisPhysical SciencesMedicineGestationHEALTHINTERVENTIONChildhood ObesityEndocrine Disorders03 medical and health sciencesHypertensive Disorders in PregnancyClinical ResearchDiabetes MellitusHumansGestational DiabetesStatistical MethodsPregnancyIndividual participant dataPreventionAustraliaBiology and Life SciencesOdds ratiomedicine.diseaseObesityGeneric health relevanceBody mass indexMathematicsDemographyPediatric ObesityNutrition and DiseasePhysiologyhumanosReproductive health and childbirth030204 cardiovascular system & hematologyOverweightMedical and Health SciencesOral and gastrointestinalCohort StudiesMathematical and Statistical TechniquesRisk FactorsVoeding en ZiekteOFFSPRING OBESITYMedicine and Health Sciences030212 general & internal medicineChildhood obesity2. Zero hungerPediatricsobrepesoMedicine (all)RObstetrics and GynecologyMetaanalysis3142 Public health care science environmental and occupational healthGestational Weight Gainobesidad pediátricaEuropeStrokePREGNANCYPhysiological Parametersgestational weight gain pregnancy obesityHypertensionFemalemedicine.symptomResearch ArticleBIRTH[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricsResearch and Analysis MethodsChildhood obesityGeneral & Internal Medicinefactores de riesgoLife ScienceObesityMetabolic and endocrineNutritionbusiness.industryíndice de masa corporalBody WeightOverweight3121 General medicine internal medicine and other clinical medicineMetabolic DisordersNorth AmericaWomen's HealthbusinessMaternal bodyGestiational diabetesWeight gainPLOS Medicine
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Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.

2021

We would like to thank all the families that participated in these studies for their generous contribution. Detailed acknowledgements and funding can be found in Sup plementary Material.

EpigenomicsMaternal smokingPlacentaGeneral Physics and AstronomyReproductive health and childbirthBioinformaticsLow Birth Weight and Health of the NewbornEpigenesis GeneticFetal DevelopmentPregnancyInfant MortalityFetal growth2.1 Biological and endogenous factorsAetiologyPediatricMultidisciplinaryQSmokingCord bloodDNA methylationEpigeneticsFemalemedicine.symptomScience1.1 Normal biological development and functioningInflammationFetus -- Trastorns del creixementBiologyGeneral Biochemistry Genetics and Molecular BiologyArticleGenetic HeterogeneityGeneticPretermUnderpinning researchTobaccomedicineGeneticsHumansEpigeneticsConditions Affecting the Embryonic and Fetal PeriodsNucleotide MotifsPregnancyHormone activitydNaMGeneral ChemistryEpigenomeDNA MethylationPerinatal Period - Conditions Originating in Perinatal Periodmedicine.diseaseEmbarassades -- Consum de tabacGood Health and Well BeingRisk factorsEpigenesis
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Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, …

2019

ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gesta…

Gestational hypertensionand promotion of well-beingNutrition and DiseaseBirthweightReproductive health and childbirthLow Birth Weight and Health of the NewbornCardiovascularMedical and Health SciencesDISEASECohort Studies0302 clinical medicine3123 Gynaecology and paediatricsRisk FactorsPregnancyVoeding en ZiekteInfant MortalityOdds RatioMedicineBirth Weight2.1 Biological and endogenous factorsEPIDEMIOLOGYwq_200Aetiology2. Zero hungerPediatricRISKeducation.field_of_studyOUTCOMES030219 obstetrics & reproductive medicineObstetricspregnancy complicationsDiabetesObstetrics and GynecologyGestational ageweight gainASSOCIATIONGestational Weight GainGestational diabetesEuropeBirthweight ; Body Mass Index ; Pregnancy Complications ; Preterm Birth ; Weight GainOBESITYFemalemedicine.symptomAdultmedicine.medical_specialtyPRETERM BIRTHBirth weightPopulationGestational Agebody mass index[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricswa_310Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterPretermClinical ResearchHumanswq_100ObesityeducationObstetrics & Reproductive MedicineMetabolic and endocrineNutritionPregnancybusiness.industryContraception/ReproductionPreventionBirthweight; body mass index; pregnancy complications; preterm birth; weight gainAustraliaInfantbirth weightpreterm birthDIABETES-MELLITUSPreterm birth weight gainOverweightPerinatal Period - Conditions Originating in Perinatal Periodmedicine.diseaseNewbornPrevention of disease and conditionsReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Good Health and Well BeingNorth America3.1 Primary prevention interventions to modify behaviours or promote wellbeingpregnancy complicationbusinessWeight gainBody mass indexwb_200
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Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies

2020

Introduction: To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. Objective: We investigated the association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and ADHD in a collaborative study including nine European population-based studies, encompassing 4,826 mother-child pairs. Methods: Concentrations of PFOS and PFOA were measured in maternal serum/plasma during pregnancy, or in breast milk, with different timing of sample collection in each cohort. We used a validated pharmacokinetic model of pregnancy and lactation to estimate…

MaleHealth Toxicology and MutagenesisReproductive health and childbirth010501 environmental sciencesToxicology01 natural sciencesMedical and Health SciencesCohort Studies0302 clinical medicinePregnancyMedicine2.2 Factors relating to the physical environment030212 general & internal medicineAetiologyChildPediatricFluorocarbonsEarly life3. Good healthPeer reviewMilkBreast FeedingMental HealthAlkanesulfonic AcidsMeta-analysisChild PreschoolPrenatal Exposure Delayed EffectsEnvironmental PollutantsFemaleCaprylatesHumanPopulationMEDLINEMothers03 medical and health sciencesEnvironmental healthmental disordersHumansPreschool0105 earth and related environmental sciencesMilk Humanbusiness.industryResearchPublic Health Environmental and Occupational HealthEuropean populationEnvironmental Exposurebiochemical phenomena metabolism and nutritionAttention Deficit Hyperactivity Disorder (ADHD)Attention Deficit Disorder with HyperactivityAttention deficitbusinessEnvironmental SciencesEnvironmental Health Perspectives
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Needs and preferences of women with prior severe preeclampsia regarding app-based cardiovascular health promotion

2022

Abstract Background Women with prior severe preeclampsia are at an increased risk for cardiovascular diseases later in life compared to women who had a normotensive pregnancy. The objective of this study was to assess their needs and preferences regarding app-based cardiovascular health promotion. Methods Patients (n = 35) of the Follow-Up PreEClampsia Outpatient Clinic (FUPEC), Erasmus MC, the Netherlands, participated in an anonymous online survey. The main outcomes under study were women’s needs for health behavior promotion, and their preferences with respect to intervention delivery. Descriptive statistics were used to evaluate needs, and thematic analysis was used to analyze preferenc…

Maleand promotion of well-beingnaisetcardiovascular health promotionmieltymyksettarpeetHealth BehaviorReproductive health and childbirthNursingHealth PromotionCardiovascularterveyden edistäminenPaediatrics and Reproductive MedicinepreeclampsiaPre-EclampsiaSDG 3 - Good Health and Well-beingClinical ResearchPregnancyBehavioral and Social SciencemobiilisovelluksetHumansObstetrics & Reproductive Medicineneeds and preferences assessmentNutritionPreventionObstetrics and GynecologyGeneral MedicinePrevention of disease and conditionsMobile ApplicationsStrokeGood Health and Well Beingintervention designReproductive Medicinepre-eklampsiaterveyskäyttäytyminenHypertensionPublic Health and Health Servicessydän- ja verisuonitauditinterventiohoito3.1 Primary prevention interventions to modify behaviours or promote wellbeingFemaleSugarsBMC Women's Health
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